There are many types of anti-mitochondrial antibodies, and different types can be seen in different diseases. Positive antimitochondrial antibodies can be found in chronic active hepatitis, systemic lupus erythematosus, autoimmune hemolytic anemia, hepatitis caused by certain drugs, and cardiomyopathy, etc. Especially in patients with primary biliary cirrhosis, the antimitochondrial antibodies will be significantly elevated, and it can be used as an important diagnostic laboratory indicator. However, there is no significant correlation between the antimitochondrial antibodies and the severity of the disease, the specific stage of the disease and the effect of clinical treatment. Even if patients with primary biliary cirrhosis have significant relief of clinical symptoms and other indicators have improved after treatment, the antimitochondrial antibodies may still be positive.