High phosphocreatine kinase isoenzyme usually indicates that a patient is experiencing symptoms of myocardial necrosis or injury. Increased phosphocreatine kinase isoenzyme is an increase in creatine kinase isoenzyme above the normal value. Creatine kinase isoenzyme is a cardiac enzyme that is a specific marker for myocardial necrosis or injury. An increase in the isoenzyme usually indicates that myocardial necrosis or injury has occurred. Typically, an increase in creatine kinase isoenzyme is seen in patients with acute myocardial infarction or myocarditis, and further testing is needed to determine the cause of the increase. In addition, in patients with acute myocardial infarction, in addition to an increase in isoenzymes, there is often severe chest pain and a significant increase in troponin in the blood. Therefore, if a patient’s examination report shows high phosphocreatine kinase isoenzyme, he or she should go to the hospital for a comprehensive diagnosis in a timely manner to clarify the cause of the disease and receive early treatment according to medical advice.