It is not recommended to take spironolactone and valsartan together, because spironolactone is a potassium-protective diuretic, which may cause elevated blood potassium in the body during use, and may also cause elevated blood potassium when using valsartan, so if spironolactone and valsartan are used together, it is easy to cause elevated blood potassium in the body and accidents. It is generally recommended to use valsartan and hydrochlorothiazide together. Hydrochlorothiazide is a potassium-removing diuretic, and the use of valsartan and hydrochlorothiazide together will not cause an increase in blood potassium. Valsartan belongs to a kind of blood pressure lowering drug, when using valsartan to lower blood pressure must regularly measure the blood pressure index, according to the blood pressure high and low to adjust the drug. Spironolactone is a diuretic drug and may cause increased urination after use, so it is recommended to take this type of diuretic drug in the morning.