Whether a high bile acid is a generalized itch or an itchy stomach varies from person to person. Generally, itching will start from the palms of the hands and feet and gradually spread to the whole body, and prompt medical attention is recommended. Bile acids are synthesized in the liver and combined with glycine or taurine to become conjugated bile acids, which are indicators of liver and gallbladder disease. Its elevation is mostly caused by improper diet, or by biliary stones, hepatitis, cholestasis, cirrhosis, chronic ethanol intoxication, etc. Clinical symptoms of the above diseases, such as nausea, jaundice, abdominal distension, etc., may be manifested. Itching due to high bile acids may be caused by cholestasis, which usually occurs during pregnancy. In cholestasis, bile acid salts are deposited under the skin, causing irritation to the nerve endings of the skin, which can lead to itching. This itching usually starts on the palms of the hands and feet and gradually spreads to the whole body, and may also be manifested as itching on the belly. These symptoms should be taken seriously and treated promptly.