Nodules in the breast can manifest as calcifications, specifically large calcifications and microcalcifications. Coarse calcifications are commonly seen in benign breast disease and can manifest as an intact mass within the envelope of the breast gland, as well as localized calcifications. Patients can also present with painful symptoms, especially if they have a long history, and localized calcifications can occur with calcium salt deposits, which usually do not require treatment. Fine calcifications, on the other hand, mainly occur in malignant tumors of the breast and are also associated with abnormal local hormone levels of metabolism, resulting in uneven local deposition of calcium salts, mainly manifested as gravel-like calcifications in clusters. If there are more than 15 calcifications per square centimeter, the possibility of a malignant lesion is highly suspected. Therefore, if necessary, the nodules in the mammary glands need to be removed promptly for pathological examination, and if they are malignant, they need to be removed radically.