Mycosis fungoides generates drug resistance, which is caused by the lack of timely treatment when mycosis fungoides develops to a serious degree. It is recommended to change the drug treatment under the guidance of the physician, and pay attention to life conditioning. 1. Replacement of drugs: patients should promptly follow the doctor’s instructions to change drugs in time for treatment, such as fluconazole capsules, can be replaced with miconazole nitrate cream, while cleaning with sodium bicarbonate solution injection every night. If the symptoms are serious, you can take oral fluconazole tablets, itraconazole capsules for joint use. 2. Pay attention to life regulation: mycosis fungoides must be treated thoroughly and effectively, otherwise it is easy to recur. During the period of treatment, the patient’s underwear should be changed frequently and scalded with boiling water and exposed to sunlight, an effective measure to completely eliminate fungal molds. It is recommended that when using medication, it should be used under the guidance of a physician. During treatment, personal hygiene should be observed.