Blisters on the feet, which are clinically known as blisters, may be caused by eczema, athlete’s foot or friction, etc. Patients can improve their condition through general treatment, medication, avoiding friction, and extraction of blister fluid. 1. Eczema: Eczema patients should avoid contact with allergens and reduce external stimuli, such as hot water scalding, violent scratching, excessive rubbing and so on. Patients can use topical medications under the guidance of a doctor, such as glycerin lotion, esacridine solution, dexamethasone cream, etc., and oral antihistamine drugs such as loratadine for severe cases. 2. Tinea pedis: For patients with blisters caused by tinea pedis, topical medications such as clotrimazole ointment, naftifine cream, etc. can be used as prescribed by the doctor; patients with exudate can use 3% boric acid solution, 0.1% Livanol, etc., and the patients can also take antifungal medications orally, such as terbinafine, itraconazole and other systemic treatments. 3. Friction: wearing unsuitable shoes or long-distance trekking friction foot blisters, need to pay attention to avoid friction, small blisters can subside on their own, large blisters need to be discharged blisters, the local use of erythromycin and other drugs to fight infection, need to pay attention to the professional physician to carry out aseptic operation. It is recommended that patients strictly follow the doctor’s instructions, actively cooperate with the doctor’s treatment, pay attention to the monitoring of the condition in life, if the condition continues to worsen, you should consult a doctor in a timely manner.