Running knee pain can be treated with physical therapy, medication and surgery. 1. Physical therapy: if the symptoms of running knee pain are mild, it is generally considered to be caused by ligament injury or knee joint strain due to sports injury, and the pain can be basically relieved after resting, cold compresses and physical therapy. 2. Medication: If running knee pain is accompanied by obvious localized swelling of the knee joint, you can choose pain relieving and anti-inflammatory medications such as Celecoxib and Meloxicam under the guidance of a professional physician for treatment. 3. Surgery: Running knee pain and accompanied by obvious pressure pain in the surrounding ligament area usually suggests that the degree of injury may be more serious, possibly due to meniscus tear, need to further improve the knee MRI and other examinations, and in serious cases, need arthroscopic minimally invasive surgery. If you feel uncomfortable, you need to improve the relevant examinations under the guidance of a doctor to clarify the diagnosis and standardize the treatment to avoid delaying the condition.