How much does the hepatitis B vaccine cost? The hepatitis B vaccine is divided into two types: domestic and imported. The domestic vaccine is usually about 20-40 yuan, while the imported vaccine is about 100 yuan, not more than 200 yuan. The hepatitis B vaccine is a vaccine included in the national immunization program and is provided free of charge by the state, but only three injections are given to infants free of charge, i.e. the first injection at birth is the basic immunization, then the second injection is given one month later, and the third booster injection is given at six months of age. The durability of protective antibodies after vaccination varies somewhat from person to person, but generally speaking, three years is guaranteed, and even a little longer, five years is guaranteed. Some children will not have sufficient antibody levels to protect them after 3-5 years, so a booster vaccination is needed at this time.