The cost of H. pylori treatment ranges from $200-600, depending on the medication regimen, drug manufacturer, course of treatment and other factors, the cost varies, it is recommended that the local hospital prices prevail. According to our guideline recommendation, the program of eradicating H. pylori most often use 2 antimicrobial drugs combined with proton pump inhibitors as well as bismuth agent quadruple therapy, the course of treatment for 14 days, in addition to triple therapy and double therapy and so on. Antimicrobials include amoxicillin, clarithromycin, tetracycline, levofloxacin, etc., proton pump inhibitors include omeprazole, rabeprazole, etc., and bismuth includes bismuth potassium citrate and bismuth pectinate. Because of individual differences, the medication is also different, and the combination of drugs as well as different drug manufacturers will affect the cost of treatment. In addition, after the treatment of H. pylori, a review is needed, and if the eradication effect is still not achieved, it is necessary to adjust the medication and carry out the treatment again. To sum up, the cost of H. pylori treatment fluctuates greatly, depending on the medication regimen, drug manufacturer, and course of treatment, etc. It is recommended to follow the doctor’s instructions and individualize the treatment with the aim of eradicating H. pylori.