A neonatal jaundice index of 20mg/dL has the potential to impair brain development and early medical attention is recommended. During the first week of life, bilirubin levels in most infants exceed the upper limit of normal, but not more than 15mg/dL. A neonate with a jaundice index of 20mg/dL is considered pathologically jaundiced, and if the jaundice index continues to rise and worsens it may lead to hyperbilirubinemia, which can cause bilirubin encephalopathy, which can lead to newborn brain damage and neurological dysfunction. It should be noted that when the neonatal jaundice index continues to rise above the normal value, prompt medical treatment should be sought. Whatever the cause of the abnormally elevated bilirubin, above the normal value, it may lead to hyperbilirubinemia. If hyperbilirubinemia is treated promptly, early treatment can reduce the adverse neurological prognosis and minimize the sequelae. If the bilirubin of a newborn baby rises above the normal value, it is important to consult a doctor and cooperate with him or her to avoid missing the optimal time for treatment, which may lead to a serious condition.