Small lymphocytic lymphoma can be treated by chemotherapy and hematopoietic stem cell transplantation. 1. Chemotherapy: chemotherapy drugs are used to control the growth and spread of cancer cells. During chemotherapy, some patients may suffer from nausea and vomiting, loss of appetite and diarrhea, etc. They can choose to consume high-calorie and high-protein food. It is also necessary to improve the patient’s immunity. Chemotherapy drugs include cyclophosphamide, vinblastine and so on. 2. Targeted therapy: such as rituximab can be used in the treatment of small lymphocytic lymphoma. 3. Hematopoietic stem cell transplantation: Hematopoietic stem cell transplantation is carried out after patients undergo chemotherapy and radiotherapy, which is mainly to introduce hematopoietic stem cells and hematopoietic progenitor cells into patients through intravenous infusion, and it can rebuild the hematopoietic system and immune system of patients. It is important to prevent the occurrence of co-infections after transplantation. Medications include ofloxacin, etc. Patients suffering from small lymphocytic lymphoma must choose the appropriate treatment under the guidance of the doctor.