Unclear borders of white patches on the back of hands can be treated by medication, non-medication and other methods. The unclear border of white spots on the back of the hand is considered to be caused by vitiligo, florid chaff rash, white chaff rash and other causes, and the treatment should be chosen according to the cause of the disease. 1. Vitiligo: When you go out, you should do a good job of sunscreen, avoid strong sun exposure. You can choose to use topical dexamethasone ointment, tacrolimus ointment, carboplatin ointment and other drugs, oral prednisone tablets and other drugs if necessary, but also skin grafting, laser and other methods of treatment. 2. Streptococcal furuncle: keep the affected area clean, do not scratch the affected area or scalding. You can choose to use ketoconazole cream, miconazole cream, clotrimazole ointment, etc., if necessary, oral terbinafine tablets, itraconazole capsules and other drugs for treatment. 3. White chaff rash: you can use warm water to wash, avoid using cleaning products to over-wash, generally no special treatment, can subside on their own. But can use urea ointment, vitamin E cream, compound vitamin B tablets and other drugs to promote the recovery of the condition. It is recommended to go to the hospital in time for examination and diagnosis, to clarify the cause of the disease, under the guidance of professional physicians, combined with their own situation for targeted treatment. The above drugs should be used in accordance with medical advice.