Fluctuations in syphilis antibody titers (concentrations) are usually due to a change in syphilis condition or other diseases. 1. Syphilis disease transition: If the disease progresses, the syphilis antibody titer will increase, and after treatment, the disease improves, the syphilis antibody concentration will decrease, and the fluctuation of syphilis antibody concentration is related to the treatment. 2. Other diseases: when the patient suffers from some diseases, such as AIDS, systemic lupus erythematosus, scleroderma and other immune system diseases, the results of syphilis spirochete non-specific antibody test can be false-positive, and some women may also have a false-positive reaction during pregnancy, which may lead to changes in syphilis antibody concentration. If the syphilis antibody concentration fluctuates, it is necessary to consult a doctor in time to clarify the cause of the fluctuation, and carry out reasonable diagnosis and treatment under the guidance of the doctor to avoid aggravating the condition.