Mannitol does not exist drug resistance, drug resistance, also known as drug resistance, refers to microorganisms, parasites, and tumor cells for chemotherapy drug tolerance, once resistance arises, the chemotherapeutic effect of the drug will be significantly reduced. Mannitol is a kind of hypertonic drug, the main mechanism of action is to make the brain tissue undergo osmotic dehydration, so that the brain water content is reduced, so as to achieve the purpose of reducing intracranial pressure. Mannitol is used to treat cerebral edema caused by various reasons, reduce intracranial pressure, prevent brain herniation, but also can effectively reduce intraocular pressure, applied to other intraocular pressure-lowering drugs are ineffective, or intraocular surgery, such as pre-preparation. Drug resistance is a decrease in the effectiveness of a drug in treating a disease or improving symptoms. When insufficient concentrations of a drug are used to kill or inhibit a pathogen, residual bacteria may have the ability to resist such a drug. Resistance can be categorized as acquired or natural based on why it occurs. Mannitol as a dehydrating drug is not resistant. If you have cranial hypertension or other discomforts, you should consult a doctor in time and be treated under the guidance of a professional physician, rather than blindly treating the problem on your own, which may cause adverse consequences.