With the right medication, the vaginal bleeding will decrease significantly after 24 hours of dydrogesterone use and will stop within three days. If the vaginal bleeding increases during the course of the medication and does not stop after three days, the medication should be considered inappropriate and the treatment regimen should be changed. Dydrogesterone is a progestin that requires a certain dose of estrogen in the patient’s body to function, so when vaginal bleeding is determined to be caused by an endocrine disorder and the estrogen level is low, estrogen should be used to stop the bleeding or estrogen should be used before progestin. If the bleeding is caused by other reasons, such as polyps in the endometrium, fibroids, adenomyosis, or suspected tumors in the endometrium of the cervix, the patient’s use of dydrogesterone has no effect and must be treated symptomatically. It is necessary to improve the examination first to clarify which cause is responsible and then treat according to the cause.