With the progress of society, the popularization of science, people’s health knowledge has generally improved, the most obvious many families have a small medicine box, sounds like a small medicine box, but if you really look at the “small medicine box”, it is really not simple, there are several kinds of Chinese and Western medicine for the treatment of colds, anti-inflammatory antibiotics for fever, a variety of sarsen Tablets and capsules, there is a sleep medicine for sleepless nights, governance diarrhea and stomach medicine, management of trauma skin swelling medicine, etc. Sometimes I joke with the owner of the medicine box: “You are not a “small medicine box”, it is simply a hospital pharmacy.” Since there are so many so full of a variety of drugs, of course, the family and even including the nearby people a little sick, the owner of the medicine box will listen to the “patient”, generously open the box to the medicine. Of course it is good to help others to relieve their pain, but before giving the medicine must understand the pharmacological effects and side effects of the drug, and even understand the side effects are more important than what these drugs cure. In recent years, the variety of drugs has increased rapidly, and there are many drugs with compound ingredients on the market (such as Advil, a common drug for fever, headache, neuralgia, rheumatic joint pain, and menstrual pain in women, which is chemically called compound aminopyrine, but is actually made by mixing three drugs together, namely barbiturate, aminopyrine, and antipyrine), and some Chinese preparations have added western ingredients. The so-called nutritional supplements also include a lot of drug ingredients, and there are even some drugs whose chemical composition is one, but the trade name is several names, this name and that name is essentially a drug, so there is improper use of drugs and can not be the right medicine; or repeated use of allergenic drugs caused by drug reactions; or drug side effects damage to the body, and even cause another disease. Today we talk about which drugs in the process of treatment may affect sexual function. First, is the antihypertensive drugs. Now the elderly suffer from hypertension, although the degree of hypertension is not the same, but more or less always have to take some drugs, so the market and hospitals have a lot of drugs to treat hypertension, a variety of drugs for hypertension point of action is not the same, some make the peripheral sympathetic nerve tension decreased, the heart rate slowed; some vasodilators can dilate small arteries, reduce peripheral blood flow resistance to lower blood pressure; also through the diuretic mechanism to reduce There are also inhibitors of angiotensinase. Although various drugs for hypertension have different effects on sexual function, but in general, antihypertensive drugs are still the most common drugs that affect male sexual function. Some studies have shown that 25% of patients taking long-term antihypertensive drugs may experience impotence, while only 7% of the control group without drugs experience impotence, much lower than the drug-taking group; at the same time, about 25% of long-term users of antihypertensive drugs experience ejaculatory disorders, some of which may cause hypersexuality or loss of orgasm not only in men but also in women, such as methyldopa, hydrazinpyridazine, colistin, insulin Lixin, blood pressure, etc. Second, is the diuretic drugs. The current treatment of hypertension is often anti-hypertensive drugs and thiazide diuretics used in combination to achieve good antihypertensive effect. It should be noted that: clinical findings of long-term high doses of thiazide diuretics, especially hydrochlorothiazide (also called dihydroketorol), about 5% of male patients can occur drug-induced sexual dysfunction. Long-term application of diuretics such as tachyphylaxis can induce hypokalemia, and impotence can occur in 5% of male patients, and this impotence can be improved after potassium supplementation. Another diuretic, anisodone, can cause not only male hypogonadism and impotence after long-term application, but also female menstrual irregularities, amenorrhea, and even the cessation of ovulation. There is also a diuretic called prazosin also affects male libido, more affects female libido, so that the female vaginal slippage is not enough, orgasm disorder, etc.. Third, is the hormone drugs: two categories: (i) anti-androgen drugs: is a large class of drugs that can reduce or antagonize the effects of androgens, its mechanism of action and androgen receptors to produce competitive inhibition. Among them, steroidal anti-androgenic drugs, including Angioprogesterone, estradiol, Cyproterone acetate, etc. can make men’s libido diminish, erectile dysfunction, and orgasmic response decrease; the other category is non-steroidal anti-androgenic drugs represented by ethylene estradiol and its derivatives, which are used to treat prostate enlargement and prostate cancer, etc. These patients not only experience gynecomastia, but also have decreased libido, impotence, ejaculation disorder and The side effects of reduced semen volume. Another category of hormonal drugs is adrenocorticosteroids, which are commonly used glucocorticoids, such as prednisone (prednisone), prednisolone (prednisolone), dexamethasone, betamethasone, etc. These drugs are commonly used in internal medicine, pediatrics, dermatology, and you listeners are familiar with the names of these drugs, do you know? When these drugs are used for too long, the dose is too large, not only can cause elevated blood sugar, blood pressure, osteoporosis and even femoral necrosis and other such serious comorbidities, but also lead to sexual dysfunction, but also can cause women’s menstrual disorders. Fourth, the class is diet pills. In recent years, the society is popular weight loss, many people, especially some girls in order to body slim with the help of drugs to lose weight. Do you know, diet pills are dependent on appetite suppression, so that you do not eat to become thin, and even make people suffer from anorexia nervosa. Remember that we have a program about “obesity and sexual health”. It was mentioned that not only excessive obesity can seriously affect the sexual health of both sexes, but also excessive weight loss after suffering from anorexia nervosa can also have a negative impact on human sexual psychology and sexual physiology. Many weight-loss drugs suppress both appetite and female sexual desire at the same time. For example, fluoxyprofen hydrochloride and other diet pills are a powerful appetite suppressant, with the effect of reducing weight, and fluoxyprofen can increase the body’s secretion of 5-hydroxytryptamine, and 5-hydroxytryptamine this substance can inhibit female sexual vitality, when women take fluoxyprofen for weight loss, there are up to 85% of people with a reduced sex drive. So women lose weight (of course, including a few men lose weight) should be careful with the drug. Fifth, is sedative, hypnotic drugs. Sedative, hypnotic drugs are drugs that inhibit the central nervous system to cause sedation and sleep. Commonly used barbiturates, non-barbiturates, as well as Valium, Scholastin, Advil, etc.. Long-term use of barbiturate sedatives can cause menstrual irregularities in women, while men may have decreased libido, poor erection or loss of orgasmic response. Large doses of Valium directly on the limbic system of the brain has a specific effect, can directly reduce sexual function, and muscle relaxation, through the spinal cord efferent nerve can cause hypoactive sexual desire or impotence, for women can also cause menstrual disorders and oocyte damage. Sixth, anti-psychotic drugs: (i) antipsychotic drugs such as chlorpromazine, methiodiazine, Telden, endo, etc. can inhibit gonadotropin secretion, so that the seminal vesicle expansion muscle paralysis, but also inhibit the penile cavernous body filling and sperm discharge capacity, so that patients occur impotence and ejaculation difficulties. In some cases, they cause a decrease in testosterone levels and impaired sperm production. The incidence of methothiopyridazine is as high as 60%, while the incidence of other drugs is about 25%. (ii) Antidepressants such as promethazine, doxorubicin, and amitriptyline. Sexual dysfunction caused by antidepressants mostly occurs when the patient’s depression is in remission, that is, when the drug shows efficacy (indicating that it is related to the drug). It is common to have decreased libido in men and women, with men showing erectile difficulties and ejaculation inhibition; women presenting insufficient vaginal secretion and difficulty in sexual intercourse. In addition to so many drugs just mentioned, some other drugs such as anti-gastrointestinal spasm drugs like belladonna, 6-542, gastric regain will reduce smooth muscle tension, so that men have poor erection, decreased libido, sexual inhibition; treatment of gastric ulcer drug methocarbamol can inhibit libido; there are long-term use of glutathione, especially in large doses, may appear impotence. Therefore, we must not underestimate the side effects of these commonly used drugs, especially on sexual function, and must apply them reasonably under the guidance of a professional doctor when choosing them, according to their specific condition, to minimize the side effects of drugs affecting sexual health.