In order to further determine the type of penile erectile dysfunction and provide a reliable basis for clinical treatment, pharmarcopenile duplex color doppler ultrasonography (PPDCDU) was used in the detection of penile erectile dysfunction. Between December 2005 and May 2006, 60 patients who came to our department for penile erectile dysfunction or requested sexual function evaluation, including age 22-59 years (mean age 34.86±9.35 years); marital age 1 month-36 years, duration of penile erectile dysfunction 1 month -7 years (mean 11 months); the mean International Questionnaire of Erectile Function (IIEF-5) score was 6.4. The changes in size and internal echogenic signals of the three cavernous bodies of the penis in the non-erectile state were observed with a color Doppler ultrasound wideband frequency conversion probe (10-12 MHz), and the changes in the internal diameter of the penile arterioles, peak flow velocity, end-diastolic flow velocity, and resistance index were measured; the penile root was then tied with a rubber band, routinely sterilized, and prostaglandin E1 was injected into the cavernous bodies of both sides of the penis with a 4-gauge needle. (trade name Kaiser 10 micrograms/branch) 1ml (5 micrograms/side), induce penile erection under audiovisual stimulation, and measure the cavernous artery and deep dorsal vein hemodynamics after penile erection. There were 11 cases (18.33%) of arterial erectile dysfunction (PSV25cm/s, EDV5cm/s, RI0.8), 20 cases (33.34%) of venous erectile dysfunction (PSV25cm/s, EDV5cm/s, RI0.8), 3 cases of arteriovenous dysfunction (PSV25cm/s, EDV5cm/s, RI0.8) (5.00%), and non-vascular erectile dysfunction (PSV25cm/s, EDV5cm/s, RI0.8) in 26 cases (43.33%). Color Doppler combined with intracavernosal injection of vasoactive substances in the penile corpus cavernosum can not only determine vascular or non-vascular ED, but also determine the hemodynamic changes of the penile corpus cavernosum arteries during erection, and further determine the type of vascular ED according to its hemodynamic characteristics. The method is highly reliable, reproducible, less invasive and easy to perform, and can differentiate between arterial and venous ED, and can be used as a key screening test before arteriography, cavernous manometry and cavernosography. The application of PPDCDU in ED diagnosis is increasingly respected by scholars at home and abroad, and has become the primary means of diagnosing ED.