What is the aspirin triad?

Aspirin triad, also known as aspirin intolerance triad or Widal syndrome, is a respiratory hyperresponsiveness disorder of unknown origin. These patients are often associated with aspirin-specific reactivity, nasal polyps and bronchial asthma. Non-steroidal anti-inflammatory drugs such as aspirin and anti-inflammatory pain can often trigger rhinitis in patients, with symptoms such as sneezing, clear nasal discharge or asthma attacks, as well as urticaria and angioedema. The disease is often similar to nasal and bronchial allergic reactions and can be associated with both rhinitis and bronchial asthma, and asthma symptoms are triggered or aggravated by aspirin. Nasal polyps are usually bilateral and multiple, and they tend to recur even after surgical treatment, and are associated with abnormal smell. The incidence of nasal polyps and bronchial asthma increases with the duration of the disease. In addition, aspirin triad is more common in middle-aged people, with an age of onset of 20-50 years, with slightly more female patients than male, in a ratio of 3:2. Very few patients may have a family history of aspirin intolerance.