High-flow pancreatic leakage, abdominal infection, and abdominal bleeding after Whipple’s operation seem to be three different complications, but in fact, they are “three brothers”, which often follow each other and become a surgeon’s nightmare. To prevent these three complications, the management of pancreatic dissection and pancreatic dissection-gastrointestinal tract reconstruction are the most important. The pancreatic dissection must be closed with 3-0 Prolene interrupted U-sutures, or double U-sutures if necessary (upper and lower margins of the pancreas), and the bleeding point of the pancreas must be tied with 5-0 Prolene sutures. It is also very important to reconstruct the pancreatic dissection with the GI tract in such a way that the pancreatic dissection is in close proximity to the GI plasma membrane rather than immersed in the digestive fluid inside the anastomosis to prevent bleeding from the pancreatic dissection. The preferred anastomosis is the pancreatic duct-jejunum mucosa-to-mucosa anastomosis, followed by the pancreatic duct-gastric mucosa-to-mucosa anastomosis advocated by Prof. Shuji Peng. With the progress of anastomosis, perhaps all pancreaticoduodenectomies in the near future will be able to achieve pancreatic duct-jejunum mucosa-to-mucosa anastomosis; pancreatic leakage and bleeding from the severed end of the pancreas will become rare complications. In addition, whether the hook is completely resected is related to the postoperative abdominal fluid, so it is important to completely resect the pancreas of the hook. (Screenshot of my surgical video of a pancreatic duct-jejunal mucosa-mucosa anastomosis, pancreatic duct diameter about 0.5 cm, anastomosis: outer 3-0 prolene jejunal plasma membrane-pancreatic dissection, inner 5-0 dexon interrupted pancreatic duct-jejunal mucosa-to-mucosa, pancreatic duct stent placed inside the anastomosis).