High C-reactive protein and fever in children can be caused by bacterial and viral infections, as well as immune system disorders that result in inflammation. C-reactive protein is easily detected as elevated when the body is in a state of inflammation, but lacks specificity and is difficult to point to a specific disease. high C-reactive protein with fever in children is most often seen in bacterial or viral infections, while viral infections can be non-elevated or mildly elevated. In addition, it may also be caused by immune system disorders, such as systemic lupus erythematosus due to genetics, pediatric Schi-Yo syndrome, pediatric aortitis and other causes of the immune system abnormalities of inflammation, may also cause low fever, high C-reactive protein. There are other reasons for high C-reactive protein and fever in children, and it is not possible to accurately determine the cause based on the change in C-reactive protein value and fever alone. It is recommended to follow the doctor’s instructions to carry out the relevant examination, with the help of the doctor to clarify the cause, and to carry out targeted treatment or therapy.