Patients with ankle pain can be caused by several reasons: First, inflammation: If the inflammatory disease is due to gout, rheumatoid arthritis, rheumatoid arthritis, or osteoarthritis, it can lead to ankle pain. In this case, the patient has to undergo relevant X-ray, CT, MRI examinations, and blood tests to make a diagnosis. Second, trauma: Ankle pain can be caused by trauma to the ankle joint, such as ankle cartilage injury or ankle joint impingement, which should be diagnosed by X-ray and MRI. Third, tumor: ankle pain caused by tumor, such as pain caused by tumor of the ankle bone, should be diagnosed by MRI. Fourth, large osteoarthrosis or talar necrosis: ankle pain due to large osteoarthrosis or talar necrosis is also a common cause of ankle pain.