Hypoproteinemia is one of the most common clinical manifestations in nephrology, and its diagnostic criterion is blood albumin <30 g/L. The most common cause of hypoproteinemia is nephrotic syndrome. After this condition occurs, the first step is to check the urine routine and the urine protein quantification. If the urine protein quantification is >3.5g, it can be diagnosed as massive proteinuria and also clinically diagnosed as nephrotic syndrome. The next step of treatment is to first check the kidney puncture to clarify the specific pathological type, the more common types are microscopic lesions, thylakoid glomerulonephritis, membranous nephropathy and focal segmental glomerulosclerosis. For example, microscopic lesions can be treated with hormones alone, while membranous nephropathy can be treated with ACEI or ARB drugs for six months, and those with poor efficacy can be treated with hormones combined with immunosuppressants to prevent the deterioration of nephropathy.