Alanine aminotransferase 66u/L and aspartate aminotransferase 42u/L are not serious and are slightly above normal values. The normal value of alanine aminotransferase and aspartate aminotransferase is 0~40u/L, alanine aminotransferase 66u/L, aspartate aminotransferase 42u/L belongs to the slightly higher than normal range, and it is necessary to clarify the cause of the disease and exclude the physiological factors, then carry out the relevant treatment. Physiologic factors that cause elevated alanine aminotransferase and aspartate aminotransferase are commonly found in overexertion and alcoholism. Therefore, it is necessary for patients to avoid exertion, reduce mental stress, stop drinking, and have regular checkups. Pathologic causes of alanine aminotransferase and aspartate aminotransferase elevation are mainly seen in drug-induced liver damage, hepatitis, fatty liver, and so on. It is necessary to carry out relevant examinations, such as abdominal ultrasound, hepatitis V, etc., and treat according to the cause of the disease, such as stopping the use of liver-damaging drugs, taking silymarin, etc. to restore liver function. Elevated alanine aminotransferase and aspartate aminotransferase need to be further examined to determine the cause of the disease, and medication should be taken under the guidance of a professional physician to alleviate the condition.