Lupus nephritis type 5 is more serious and may cause complications such as blood clots, acute renal failure or continue to develop into lupus nephritis type 6 and progress to uremia. Lupus nephritis is a serious renal complication of SLE. The pathological manifestation of lupus nephritis type 5 is mainly membranous lupus nephritis, and the patient will have nephrotic syndrome manifestations such as large amount of proteinuria, hematuria, hypoproteinemia, edema, etc., which can cause serious complications such as infections, thromboembolism, and acute renal failure, and threaten the patient’s life. If lupus nephritis type 5 is not treated in time, the condition will continue to progress, and when it develops into lupus nephritis type 6, extensive glomerulosclerosis will occur, resulting in serious damage to the patient’s kidney function, and at this time, all kinds of treatments can’t achieve good therapeutic effect, and the patient may eventually enter the uremic stage, which will require renal replacement therapy. Therefore, lupus nephritis type 5 should go to the regular hospital in time, under the guidance of the doctor, timely treatment, to avoid further development of the disease.