Usually, acyclovir cream has no therapeutic effect on herpes perspiration, and is not recommended. The cause of herpes sweat is not completely clear, may be related to a number of factors, such as local allergies, dermatophyte infections, psychiatric factors, ultraviolet radiation and a history of atopic dermatitis, etc. Herpes sweat is generally not related to viral infections. Acyclovir cream is mainly used for the treatment of various diseases caused by viral infections, such as herpes zoster, herpes simplex and other diseases, mainly plays an antiviral role. Sweat herpes, on the other hand, is generally not associated with viral infections, so acyclovir cream is not usually used to treat sweat herpes. Sweat herpes can be used externally with mometasone furoate cream, tretinoin urea cream and other glucocorticoid drugs to relieve itching and other symptoms; if the condition is more serious, the patient can also be under the guidance of the doctor application of dicloxacortin capsules and other antihistamines to stop itching, and even can be followed by the systematic application of prednisone acetate tablets and other glucocorticosteroid drugs treatment. Sweat herpes patients are recommended to go to the regular hospital in time, after a clear diagnosis under the guidance of the doctor standardized treatment, do not self-medication delay the condition, and even cause serious adverse reactions.