The Down’s syndrome screening done in the fourth month of pregnancy is a mid-term Down’s syndrome screening, and the cost of a mid-term Down’s syndrome screening is about$200-300. However, the uncertainty of medical fees is relatively large, depending on the level, nature and location of the hospital, as well as the methods and instruments used in the screening process, which have a greater impact on the medical fees. Especially in the case of Down’s syndrome screening in private hospitals, there may be package fees and bundled fees, which may multiply the cost of Down’s syndrome screening. The higher the level of the hospital, the more advanced the medical equipment, the higher the level of technology, and the more accurate the test, the higher the fee will be. In order to ensure accurate and reliable results, it is recommended that pregnant women have their Down’s syndrome screening done at a large public hospital, and that they inquire about the costs before the test.