Montgomery’s nodules do not appear before menstruation. Montserrat’s nodules are commonly seen in pregnant women. They are nodular protrusions in the peripheral part of the areola, formed by the bulging of the ductal opening of Montserrat’s gland. Under normal physiological conditions, the estrogen and progesterone in the body rise substantially after pregnancy, leading to the development of Montserrat’s nodules in breast tissue. During the premenstrual period, the estrogen in the body will reach a high level, which will stimulate the development of breast glands, but no Montserrat nodules will appear. It is recommended to pay attention to the hygiene of the breast area and not to deliberately knead the breast nodes or nipple area to avoid skin breakage and infection.