Long-term use of drugs will bring certain side effects, such as diuretics will cause increased urine output, beta blockers will cause arrhythmia, calcium antagonists will have gingival hyperplasia and so on. 1. Diuretics: such as spironolactone, furosemide, etc. Long-term use of diuretics such as hydrochlorothiazide may cause low potassium, low sodium and high uric acid, resulting in weakness and increased urination; long-term use of spironolactone may cause gynecomastia. 2. β-blockers: such as propranolol, metoprolol, etc., may cause arrhythmia and cold limbs and other symptoms. 3. Calcium antagonists: such as nifedipine, felodipine, etc., which may present with increased heart rate, facial flushing, headache, gingival hyperplasia, spasmodic edema of the lower limbs and vasodilation. 4. Angiotensin-converting enzyme inhibitor drugs: such as captopril, there will be irritating cough and other symptoms. If there is an adverse reaction should be timely medical care, do not stop or change the drug without authorization. If the symptoms are serious, stop the drug in time to seek medical attention.