Frequent peeling of the lips may be due to chronic desquamative labiitis, chronic photodamageable labiitis, nutrient deficiencies, etc., which can be improved by medication and enhanced care. 1. Chronic desquamative labiitis: chronic desquamative labiitis is mostly seen in women under 30 years old, mainly manifested as dry lips, cracking, yellow or brown flakes and other symptoms, the course of the disease is repeated, sometimes light and sometimes heavy, such patients can be applied locally to gentamycin ophthalmic ointment, fluoro easy ointment, tretinoin cream and other drugs to help treatment, serious cases can be taken orally at the same time to help improve the vitamin A peeling. 2. Chronic photochemical labiitis: the lips are exposed to excessive ultraviolet radiation can cause chronic photochemical labiitis, such patients are mainly manifested as lip chaffing flaking, itching symptoms are not obvious, can be perennial recurrence, last for several years, such patients can be applied locally chloroquine ointment, titanium dioxide ointment to help the lips from the sun, the serious cases need to be taken orally hydroxychloroquine sulfate, niacinamide and other drugs. 3. Nutrient deficiencies: when the patient’s body has a variety of B vitamin deficiencies, iron or zinc and other trace element deficiencies, which may lead to dry, cracked lips, peeling, chapped corners of the mouth, tongue damage and other symptoms, such patients need to standardize the supplementation of vitamin A, B vitamins, folic acid, iron, zinc and other nutrients, which helps to improve the relevant symptoms. It is recommended that patients seek medical attention in a timely manner and follow medical advice under the guidance of a physician to avoid adverse reactions.