Gallbladder stones 2cm are considered large. Gallbladder stones 2cm counts more than medium above, most of the clinical found in 1cm below, with the improvement of medical level and conditions, most gallbladder stones in the 2cm before generally be found, and in the physician’s advice most will receive cholecystectomy surgical treatment, so the gallbladder stones to reach or more than 2cm is less common. Gallbladder stones of 2cm or more, through medication and other conservative treatments are not effective, in principle, should be the main surgical treatment, mostly preferred laparoscopic cholecystectomy. When gallbladder stones are found or accompanied by obvious symptoms, they should be treated promptly. The treatment of larger stones should follow the physician’s recommendations to avoid serious complications.