There is no such thing as the most feared medication for connective tissue disease, which is usually often treated with non-steroidal anti-inflammatory drugs (e.g., loxoprofen, celecoxib), glucocorticosteroids (e.g., hydrocortisone), and immunosuppressants (e.g., methotrexate). The exact medication and treatment results will vary from person to person. Connective tissue disease is a group of diseases with unknown etiology, involving multi-organ and multi-system connective tissue, mainly including lupus erythematosus, dermatomyositis, scleroderma, dry syndrome, rheumatoid arthritis, polyarteritis nodosa and rheumatic fever. This group of diseases has some features common to autoimmune diseases, such as multiple autoantibodies can be detected in the serum, and the application of glucocorticoids and immunosuppressant treatment is effective. 1. Non-steroidal anti-inflammatory drugs: If connective tissue disease causes arthritis, joint pain and other symptoms, non-steroidal anti-inflammatory drugs such as Loxoprofen and Celecoxib can be applied for anti-inflammatory and analgesic purposes. 2. Glucocorticosteroids: such as hydrocortisone, dexamethasone, etc., can effectively improve the symptoms. 3. Immunosuppressants: such as methotrexate, cyclophosphamide and other drugs, which can relieve the condition. Patients with connective tissue disease are advised to consult a doctor in time and choose the appropriate medication under the doctor’s guidance to standardize the treatment.