Whether it is okay to take estradiol for one month needs to be determined according to whether the menstruation and endocrine condition is normal or not, and if the endocrine level returns to normal, the medicine can be stopped. Estradiol belongs to estrogen, usually applied in sequence with progesterone and other progestins, which can regulate menstruation and promote endocrine normalization, and is commonly used for irregular menstruation, endocrine disorders such as polycystic ovary syndrome, and autonomic disorders during menopause. If the endocrine level of hormone six is normal or the symptoms of autonomic nervous disorder disappear after one month, that is, one cycle, the medicine can be stopped. It is recommended to go to the obstetrics and gynecology department of the hospital for regular use of estradiol under the guidance of the doctor’s prescription and use of medication, and avoid stopping the medication privately, so as not to cause endocrine disorders.