ACEIs and ARBs not only lower blood pressure, but also protect the kidneys, while other diuretics, CCBs, beta-blockers, etc. also have antihypertensive effects and do not harm the kidneys. 1.ACEI: Typical representative drugs such as captopril, enalapril, etc., through the blockade of angiotensin converting enzyme and thus antagonize the RAAS system, the important point is that this kind of drugs can reduce the hyperperfusion of renal units, reduce proteinuria. However, these drugs should be used with caution in some cases, including bilateral renal artery stenosis, severe renal insufficiency (creatinine 265 mmol/l), pregnancy, hyperkalemia, and hypotension. Adverse reactions include hyperkalemia, hypotension, dry cough, transient deterioration of renal function. 2. ARB class: typical representative drugs such as valsartan, chlorosartan, etc., which antagonizes the RAAS system by blocking the angiotensin II receptor, the effect is the same as that of the ACEI class, except for the reduction of dry cough adverse reactions, other than the same as ACEI. 3. Typical representative drugs of diuretics such as hydrochlorothiazide, spironolactone, etc.; CCB class such as isobarbital, diltiazem, etc.; β-blocking drugs such as propranolol, atenolol, etc.. One of the principles of hypertension medication is the combination of drugs, if you suffer from hypertension must be under the guidance of a doctor to use drugs.