If you have dense blisters on your lips, you can deal with them as follows: 1. Drink more water, eat more fresh vegetables and fruits, and avoid spicy, fried, irritating and pickled foods. 2. Use topical acyclovir ointment and erythromycin ointment, and take oral acyclovir tablets, niuhuang detoxification pills and huanglian Shangqing pills. 3. Don’t stay up late, relax your mind and keep your bowels open. Lip blisters are generally caused by viral infections, over-eating spicy and fried food, staying up late for a long time, mental stress and other reasons.