Men’s cheeks on both sides of the long acne, generally due to the skin oil secretion is more exuberant, coupled with excessive consumption of spicy and stimulating food or excessive late-night and other factors caused; patients can be in the guidance of the doctor through the topical medication, oral medication, and general treatment and other ways to solve the problem. 1. Topical medication: If the acne is in the state of closed mouth acne, you can use topical adapalene gel at night to improve; if the acne is infected at this time, the formation of inflammatory acne, you can use topical mupirocin ointment, fusidic acid ointment, etc. to improve. 2. Oral medication: If the acne on both sides of the cheeks is more serious, it can be treated by oral medication, such as isotretinoin, minocycline hydrochloride and so on. 3. General treatment: patients should try to avoid using their hands to squeeze pimples, try to eat a light diet, and at the same time to keep the bowel movement daily. For men with acne on both sides of the cheeks, it is recommended to go to a regular hospital in time for examination, under the guidance of a professional doctor for medication. Drugs need to be used in accordance with medical advice.