Headache with generalized weakness and soreness occurs when a systemic viral infection occurs, accompanied by a vascular headache induced by the infection. Viral infections are common in upper respiratory tract infections, but can cause viremia causing a series of systemic symptoms, mainly a general feeling of weakness and weakness, with muscle aches and heavy head, sometimes accompanied by headache. Blood tests when the virus causes muscle soreness can sometimes reveal a mild elevation of creatine kinase in the serum muscle enzyme profile, blood tests suggest elevated C-reactive protein, white blood cell count can be mildly elevated or decreased, and the lymphocyte ratio is elevated. Headache is induced by infection and is a secondary vascular headache, with vasoconstriction and dilation dysfunction in the brain as the main cause, with episodes caused by vasodilation.