Today, we would like to introduce you to the common sense of changing medicine after anorectal surgery. Anal diseases due to the special site, poor exposure, and easy to be stimulated and contaminated by feces, while the surgical wounds are mostly open, most of which are located in the anus, prone to poor wound drainage, granulation, edema, bleeding, delayed healing and even wound infection, generally not easy to heal properly without changing medication. We all have a habitual thinking that once we want to operate, the first thing that comes to mind is the quality of the operation, to find a good doctor, an experienced doctor to operate, however, one event that we do not know is that the post-operative medication change is particularly important. Due to the special site, poor exposure and easy to be stimulated and contaminated by feces, at the same time, the surgical wound is mostly open, mostly located in the anus, prone to poor wound drainage, granulation, edema, bleeding, delayed healing and even wound infection, etc. It is generally not easy to heal normally without changing the medication. At the same time, anorectal surgery often has special conditions such as skin strap hanging, ligature line, counter drainage, etc., which need to be observed and dealt with in a timely manner when changing medication. Therefore, postoperative medication changes are particularly important, and there is even the saying “three points of surgery, seven points of medication changes”. The recovery period of the wound is divided into three phases: inflammatory phase, fibrous proliferation phase, and epithelial coverage phase, which require insistence on drug changes. Early stage: the wound is mainly inflammatory exudate, the change of medicine in this period is to clean the wound, remove foreign body and pus, make the wound drainage smooth, reduce the stimulation of bacteria and secretion, and prevent the complication of infection. Middle stage: In this period, the wound secretion decreases and the proliferation of granulation tissue predominates. Since granulation tissue is weak to external physical and chemical stimuli and vulnerable to injury, it is necessary to protect granulation tissue in this period to avoid affecting the healing of wounds. Late stage: In this stage, the wound and wound surface have been basically filled with granulation tissue, and the epithelial cells at the wound edge are close to the center of the wound surface, finally covering the wound surface and making the wound heal. Change of medication for different diseases 1. Change of medication after hemorrhoid surgery: wider radial incisions should be placed with drainage gauze to the bottom of the incision in order to make the incision heal gradually, which can avoid anal stenosis. Keep the stool open and change the medication gently to avoid violent medication changes that can cause premature dislodgement of the internal hemorrhoid ligature and bleeding or non-healing of the trauma. Observe the traumatic flesh buds, if they appear higher than the edge of the skin, they should be cut out in time, and stop ointment-based topical medication and change to aqueous solution gauze. 2, post-operative anal fissure drug change: anal fissure post-operative trauma is mostly longitudinal, change the drug when the wound to put small gauze to the bottom of the wound. Anal fissure postoperative trauma since the base healing is not narrow, not the key to recurrence. 3, abscess, anal fistula after surgery drug exchange: abscess or anal fistula after surgery in the cavity of necrotic tissue, secretions, drug change should try to remove rotten tissue, pus and blood, available saline, metronidazole and other solutions flushed. After flushing, the wound can be filled with comfrey oil gauze for drainage to drain smoothly or to avoid false healing. Many patients are overly concerned about the recovery of the anal wound after discharge, excessive cleaning and disinfection, which is also not conducive to the recovery of the wound, we still need to communicate with the doctor in a timely manner to find a suitable method of dressing change.