There is hope for IVF at age 49, but specific assessment of the physical condition of both parties is also needed. There is a chance of pregnancy for IVF at the age of 49, according to the report released by Wuhan University Center for Reproductive Medicine in September 2018, the average success rate of IVF at all ages reaches more than 70%, but specific assessment is also needed such as the condition of the uterus and its internal environment, and the couple’s lifestyles. If you are 49 years old and need to undergo IVF, you should go to a regular and professional medical institution to assess the physical condition of both parties, and at the same time, maintain a good mindset and good living habits. The mental and psychological condition of the pregnant mother has an important impact on the pregnancy, and a long-term bad lifestyle, such as smoking and alcoholism, will also reduce the success rate. It is recommended that couples preparing for pregnancy go to the hospital to do pre-pregnancy eugenics health checkups to assess whether the body is suitable for pregnancy; quit smoking and drinking, develop good living habits, and don’t stay up late. Moderate exercise to maintain good health, to avoid prolonged exposure to radiation or pollution in the environment, to get out of the toxic and harmful work environment; maintain a happy mood; avoid heavy physical labor. Preparation for pregnancy medication should be under the guidance of a doctor, careful selection of symptomatic drugs; women should start from 3 months before the planned pregnancy oral folic acid, to prevent neural tube defects; if the injection of vaccines should be completed in preparation for pregnancy, try not to be vaccinated during pregnancy.