High glutamyl transpeptidase may be associated with certain medications, alcohol abuse, liver disease, biliary tract disease, pancreatic disease, etc. 1. Drugs: Taking non-steroidal anti-inflammatory drugs such as ibuprofen, or statin drugs such as simvastatin may lead to liver function damage, which in turn may lead to elevated glutamyl transpeptidase. 2. Alcoholism: If alcoholism is chronic, it can lead to liver function damage, which may also show elevated GTP. 3. Hepatobiliary and pancreatic diseases: Hepatitis caused by various viral infections, such as hepatitis B, hepatitis E, or EBV infections, may cause elevated GTPase. Diseases such as bile duct stones, biliary tract infections, and pancreatic head tumors, if obstruction occurs at the site of the lesion, it will usually lead to blood flow disorders in the structures above the site of obstruction and induce infections, which in turn will cause elevation of glutamyl transpeptidase. There are many other causes of high glutamyl transpeptidase, it is recommended that patients go to regular hospitals in a timely manner, after clarifying the cause of the disease, under the guidance of the doctor to carry out targeted treatment or treatment, in order to reduce the adverse effects of the disease.