Sertraline and fluoxetine are generally not used together. Sertraline and fluoxetine are both antidepressants, with sertraline mainly used to treat symptoms associated with depression including, depression accompanied by anxiety with or without a history of mania, and fluoxetine can be used to treat a variety of depressive psychiatric disorders, including mild or severe depression, bipolar disorder and so on. These two drugs usually can not be taken at the same time, in the clinical treatment, often a single medication in sufficient quantity and course of treatment can be. However, each patient’s condition is different, for some of the more intractable depression, if necessary, the doctor may consider a combination of drugs, but must be guided by the doctor to use the drug. When using the drug, pay attention to the two drug components of the allergy is prohibited, after using the drug if there are serious adverse reactions, such as mental abnormalities, autonomic nervous system abnormalities, allergic reactions, etc., you need to stop the drug and consult a doctor.