Indomethacin suppositories can inhibit the synthesis of prostaglandins, with analgesic effect, on most patients with dysmenorrhea pain symptoms have significant relief. Dysmenorrhea is a common gynecological clinical disease, according to the cause, roughly divided into primary dysmenorrhea and secondary dysmenorrhea two categories, of which the primary dysmenorrhea is the most common. The main cause of primary dysmenorrhea is increased endometrial prostaglandin levels. Indomethacin suppositories can inhibit the synthesis of prostaglandins and reduce the level of prostaglandins in the endometrium, thus relieving dysmenorrhea. Common adverse reactions to the use of indomethacin suppositories include nausea, stomach pain, and headache. Indomethacin suppositories should be contraindicated in patients with active peptic ulcers, in patients with gastrointestinal perforation or bleeding following the use of nonsteroidal anti-inflammatory drugs, in patients with severe heart failure, and in patients with severe hepatic or renal insufficiency. As there are many causes of dysmenorrhea, patients with frequent symptoms of dysmenorrhea should consult a doctor in time in order to take effective treatment measures.