Gliclazide tablets and glimepiride tablets have similar effects, there is no which one is better, more still need to be combined with the patient’s situation. 1. Gliclazide tablets are second-generation sulfonylurea hypoglycemic drugs, which can be used for type 2 diabetes mellitus with unsatisfactory results after dietary control for a period of time, and are contraindicated in patients with hepatic or renal insufficiency, allergy to sulfonylureas, patients treated with miconazole, breastfeeding, and patients with porphyria. Adverse reactions such as hypoglycemia, gastrointestinal disturbances including nausea, dyspepsia, diarrhea and constipation may occur with the administration of this substance. 2. Glimepiride tablets are third-generation sulfonylurea hypoglycemic drugs, the main effect is to lower the blood glucose value in the body, suitable for controlling diet, exercise therapy and weight loss can not adequately control blood glucose type 2 diabetes mellitus. It is not suitable for type 1 diabetes. Glimepiride tablets may be taken with adverse reactions such as systemic disorders, metabolic and nutritional disorders, blood and lymphatic system disorders. It should be contraindicated in patients who are allergic to glimepiride, other sulfonylureas, other sulfonamides or any of the ingredients in this product, pregnant women, lactating women, type 1 diabetes mellitus, diabetic coma, ketoacidosis. Be aware that this product may be hypoglycemic at the beginning of treatment. Drugs no which is better, suitable for their own condition, it is recommended that patients under the guidance of a doctor to use medication, not blindly take on their own.