Mediastinal granuloma is mainly related to local inflammatory reaction, the treatment includes surgical excision, drug treatment and local radiotherapy, etc. The use of drugs should follow the doctor’s instructions. 1. Surgical excision: larger granulomas that cause compression of the surrounding tissues and result in significant abnormalities in cardiopulmonary function can be surgically excised. 2. Medication: Generally, anti-inflammatory drugs such as moxifloxacin can be applied regularly. 3. Local radiotherapy: Radiotherapy can help to improve the localized lesions, reduce the scope of localized lesions and control the progress of the disease. It is recommended that patients with mediastinal sarcoidosis should seek timely medical treatment, and carry out standardized treatment under the guidance of clinicians after diagnosis of the disease, so as to prevent the delay of the disease.