Aminotransferases usually refer to serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Transaminases are mainly found inside liver cells, and if inflammation occurs in the liver (bacteria, viruses, poisoning, alcoholism, autoimmunity, copper, fat and other metabolic disorders, etc.) can cause the release of transaminases from the liver cells into the blood, causing elevated serum transaminases. Many people, even non-hepatitis medical professionals in hospitals, tend to talk about enzymes and refer patients to hepatitis clinics or recommend isolation. First, the level of transaminases is not parallel to liver function. 1, many patients with chronic hepatitis and cirrhosis have been normal transaminases, but pathological histological examination found that the degree of liver inflammation, the level of fibrosis are heavy. Therefore, the level of transaminases and liver function are not necessarily in a parallel relationship. 2, drug poisoning, transaminases can be very high, but after stopping the drug transaminases quickly recover. In patients with severe hepatitis, jaundice is very deep, but transaminases are not high, which is medically known as “bile enzyme separation”; moreover, prothrombin time is prolonged, cholesterol is reduced, cholestrol is reduced, and cholinesterase is reduced. These are indicators of the severity of severe hepatitis in patients. In patients with biliary sweat depression, jaundice is very deep and transaminases are not very high, but prothrombin time, cholesterol and cholinesterase are in the normal range, which can be differentiated from severe hepatitis. 4. Fatty liver: diabetic patients, alcoholic hepatitis, and over-nourished, or obese patients can cause elevated transaminases, which are not infectious, but are caused by metabolic disorders. What we are discussing here is that elevated transaminases are not a specific test for hepatitis B germ-specific liver function abnormalities and cannot be equated with infectiousness, but the changes in transaminases in hepatitis B patients must be taken seriously and need to be considered in conjunction with other liver function tests. At present, in addition to HBV marker testing in hepatitis B patients, HBV- DNA testing is still required. If HBV- DNA is positive or exceeds the standard for its quantification by greater than 1000 copies/milliliter, the blood of these patients, regardless of the level of transaminases, is infectious, which is the key issue that must be taken seriously. Therefore, the correct understanding of transaminases and transaminases rose to the city system of various causes, we will not talk about the enzyme is infectious refers to the blood excretion of the germ. The main thing that should be emphasized in the future diet is to share food or eat with common chopsticks as an effective measure to prevent hepatitis. Any other disease that damages liver cells can also cause transaminases to rise. The most specific test is the genetic diagnosis of the virus (i.e. HBV- DNA). Why do patients with viral hepatitis often have elevated aminotransferases when their disease is active? Transaminases are an enzyme found in liver cells and in many organs and tissues. When an organ such as the liver is damaged or necrotic, transaminases are released into the bloodstream, causing an increase in transaminases. Serum ALT is most abundant in the liver, and the order of distribution: liver > kidney > heart > muscle; while the content of AST heart > liver > muscle > kidney. Since the activity of transaminase in the whole liver is 103-104 times higher than that of the enzyme in the serum, if 1% of the hepatocytes are hit or necrotic, the activity of the enzyme in the serum can be increased by a factor of 1. ALT reflects the degree of damage to hepatocyte plasma, while AST reflects damage to hepatocyte mitochondria.