Mid-stage breast cancer without chemotherapy is usually a no-no. Breast cancer is a malignant tumor that occurs in the epithelium of the breast. Intermediate stage breast cancer usually means that the primary tumor is large or there are axillary lymph node metastases and no distant organ metastases have occurred. Mid-stage breast cancer generally requires chemotherapy. If the cancer reaches the mid-stage, it means that the cancer cells have signs of metastasis and surgery cannot completely remove the tumor cells. Without chemotherapy, it will increase the risk of metastasis and recurrence of breast cancer and will shorten the life of the patient. Of course, for patients who cannot physically tolerate it, they can also consider dispensing with chemotherapy. Patients with mid-stage breast cancer should follow the doctor’s instructions for standardized treatment to avoid delaying their condition.