Gallstones, which include gallbladder stones, extrahepatic bile duct stones, and intrahepatic bile duct stones, may be asymptomatic or may occur with biliary colic, which varies. They are mainly diagnosed by laboratory tests and imaging tests. 1. Gallbladder stones: Patients with gallbladder stones mainly present with biliary colic, which may be characterized by severe paroxysmal pain in the right upper abdomen that radiates to the right shoulder and back. Patients may also present with vague pain in the upper abdomen, which may be accompanied by fullness and acid reflux. 2. Extrahepatic bile duct stones: Extrahepatic bile duct stones may have symptoms such as abdominal pain, chills, high fever and jaundice. 3. Intrahepatic bile duct stones: Intrahepatic bile duct stones usually have no obvious symptoms, but once there is an infection, there can be abdominal pain and fever. The diagnosis of gallstones needs to improve the blood routine and inflammation index examination, generally high leukocytes in the blood routine to consider the existence of infection, at the same time should be combined with the inflammation index for auxiliary diagnosis. It is also necessary to improve the examination of liver function to clarify whether there is jaundice. In addition, ultrasound, magnetic resonance pancreatic and biliary hydrography, endoscopic retrograde cholangiopancreatography, percutaneous hepatic cholangiopancreatography can be used to further clarify the diagnosis.