There is no quickest way to stop hiccups. You can use medication such as chlorpromazine and home remedies to control the symptoms. 1. Medications: hiccups may be caused by improper diet, stomach disease, mental stress, mediastinal lesions, etc. You can take chlorpromazine, chlorzoxazone tablets and other medications to treat them, but it may lead to constipation, diarrhea, mental anomalies, dry mouth, and other side effects, and you can also use phrenic nerve block, but it may lead to respiratory distress and other complications. 2. Home treatment: hiccups can also be covered with a paper bag over the nose and mouth in the paper bag to breathe repeatedly blowing method, or drink a large mouthful of water to contain, hold your breath to stop breathing method. All of the above medication should be used under the guidance of a doctor to avoid self-medication.