Sacubitril valsartan sodium, rivaroxaban, metoprolol succinate extended-release tablets can be taken for life if there is no special, it will affect the heart rate, bleeding, blood pressure and so on. 1.Sacubitril valsartan sodium is indicated for primary hypertension, chronic heart failure with reduced ejection fraction, and so on. Adverse reactions include hypotension, cough, hyperkalemia. Contraindications are: allergy to this drug is prohibited, diabetic patients with concomitant use of aliskiren is prohibited, angiotensin-converting enzyme inhibitors for the treatment of angioneurotic edema is prohibited, and so on. 2. Rivaroxaban is indicated for the prevention of deep vein thrombosis, treatment of pulmonary embolism and deep vein thrombosis, and patients with non-valvular atrial fibrillation. Adverse reactions include thrombocytopenia, cerebral hemorrhage, gastrointestinal bleeding, jaundice and so on. Contraindications include hypersensitivity, active pathologic bleeding, and patients with prosthetic valves. 3. Metoprolol succinate is indicated for hypertension, angina pectoris, myocardial infarction, aortic coarctation, arrhythmia and so on. Adverse reactions include decreased heart rate, hypotension, dizziness, skin rash, etc. Contraindications are contraindicated in bradycardia, in patients with sick sinus node syndrome, in patients with cardiogenic shock, and so on. All of the above drugs should be used under medical supervision.