Some people think that increased cortisol secretion may lead to protein breakdown, causing muscle atrophy, so that people who work out should lower cortisol, but this is a wrong statement. Because only in the case of long-term cortisol is more, will lead to protein breakdown, and fitness people exercise, only a short period of increased cortisol, and after the end of the exercise, cortisol will return to normal within a few hours, so normal people or fitness people generally do not need to take measures to reduce cortisol. In the case of pathological high cortisol, such as cortisolism, professional treatment is needed to reduce it. If the disease is caused by Cushing’s disease, steroid synthesis inhibitors, such as mitotane, amiloride, and methylphenidate, can be used to inhibit cortisol synthesis to some extent, and glucocorticoid receptor antagonists, such as mifepristone, can also be used.